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We all get older. But we don't all age at the same rate.
Scientists distinguish between chronological age, the number of years you've been alive, and biological age, which reflects how well the body is actually functioning. Chronological age is straightforward and unchangeable, whereas biological age is calculated from a range of biomarkers related to epigenetic clocks, chronic inflammation, mitochondrial function, cellular senescence, and telomere length. Together, these biomarkers now allow researchers to study aging-and the factors that speed it up or slow it down-without waiting 80 years to see who lives longest.
This is a significant development because, for more than a century, longevity research relied on laboratory animals that live and die quickly enough for scientists to observe entire lifespans. Those studies revealed that factors such as how much we eat, when we eat, overall dietary patterns, and even individual nutrients can influence lifespan and many of the biological processes associated with aging.
Of course, mice aren't people. While animal studies have generated many of the most exciting hypotheses in longevity science, they can't prove that the same effects occur in humans. Fortunately, researchers can now combine decades of animal research with large human population studies, randomized clinical trials, and biological markers of aging to build a much clearer picture than was possible even 20 years ago.
So, what does that picture look like? Nutrition can slow biological aging, but the evidence points to patterns, not shortcuts.
Aging isn't a single process; it's the cumulative result of countless small changes that gradually impair the function of our cells and tissues. As this damage accumulates, our risk of chronic diseases increases along with our wrinkles.
Unlike chronological age, biological age measures how ‘old’ your body is physiologically, regardless of what the calendar says. There is no single test that can perfectly capture biological age; researchers now use a variety of biomarkers to estimate it.
One of the newest and most promising tools is the epigenetic clock, which estimates biological age by analyzing patterns of DNA methylation- chemical tags attached to our genes that change predictably as we age. Several studies have found that these clocks predict disease risk and mortality independently of chronological age.
Researchers also examine telomeres; the protective caps at the ends of chromosomes that gradually shorten as cells divide. Shorter telomeres have been associated with numerous age-related diseases.
Other markers focus less on DNA itself and more on how the body functions. Persistent low-grade inflammation, also called inflammaging, is a hallmark of aging and chronic disease. Declining mitochondrial function-the ability of our cells to efficiently produce energy-is another common feature.
Yet another, is cellular senescence, the process in which damaged cells stop dividing but refuse to die, instead releasing inflammatory compounds that can impair surrounding tissues.
No single biomarker tells the whole story. But taken together, they provide researchers with an increasingly sophisticated picture of biological aging-and, more importantly, a way to measure whether various interventions slow or accelerate it.
Increasingly, the answer appears to be yes.
One of the strongest lines of evidence comes from studies examining telomere length, a widely studied aging biomarker. In an analysis of 64,690 UK Biobank study participants, each additional daily serving of ultra-processed food was associated with shorter telomeres.
Similarly, among 886 Spanish adults aged 57-91, those consuming more than three servings per day had nearly twice the odds of short telomeres compared with those consuming fewer than two servings per day.
Researchers have also found encouraging evidence in intervention studies. In one of the best-known lifestyle trials, participants assigned to a predominantly plant-based lifestyle increased telomerase activity, the enzyme responsible for maintaining telomeres, after just three months.
Five years later, participants who maintained the intervention had telomeres that were significantly longer than those of the control group. Because exercise, stress management, and social support were also part of the intervention, these results cannot be attributed solely to diet.
In a 2021 pilot randomized controlled trial, healthy men aged 50-72 followed an eight-week diet and lifestyle program emphasizing a plant-rich diet, regular exercise, adequate sleep, stress management, and selected supplements.
By the end of the study, participants had reduced their biological age by an average of 3.23 years relative to the control group, as measured by DNA methylation. While the study was small and combined several lifestyle interventions, it provided compelling proof of concept that biological age can respond to relatively short-term changes in diet and lifestyle.
In addition to telomeres and DNA methylation, researchers have also reported that nutrition can influence chronic inflammation, improve mitochondrial function, and affect other biological processes that become impaired with age.
While each biomarker has strengths and limitations, the remarkable consistency across multiple lines of evidence-including decades of animal research-has fuelled enormous interest in nutrition as a strategy for promoting healthy aging. When numerous biomarkers all respond in the same direction, the overall picture becomes much more compelling.
Over the years, scientists have studied caloric restriction, Mediterranean, plant-based, ketogenic, intermittent fasting, time-restricted eating, protein restriction, and countless individual nutrients. Although these approaches often differ dramatically, they frequently converge on the same outcomes-lower chronic inflammation, improved metabolic health, reduced oxidative stress, and better preservation of markers associated with healthy aging.
In other words, the strongest evidence points to overall dietary patterns rather than trendy supplements or specific nutrients. One of the clearest recommendations emerging from the research is to base your diet around whole, minimally processed foods.
Large observation studies consistently associate diets high in ultra-processed foods with poorer metabolic health, greater inflammation, and less favourable biomarkers of biological aging, such as telomere length. Although these studies cannot prove cause and effect, they are supported by experimental evidence showing that ultra-processed diets tend to promote oxidative stress, chronic inflammation, and poor metabolic health-all hallmarks of biological aging.
A second remarkably consistent finding is the value of plant-rich diets. Whether researchers study the Mediterranean diet, DASH diet, or predominantly plant-based eating patterns, diets emphasizing vegetables, fruit, legumes, nuts, whole grains, herbs, spices, and olive oil repeatedly rank among the healthiest for aging.
These foods provide fibre, vitamins, minerals, and thousands of bioactive compounds-including polyphenols-that appear to reduce oxidative stress and inflammation while supporting the gut microbiome. Importantly, this doesn't necessarily mean everyone should become a vegetarian. Rather, the evidence consistently favours more plants and fewer ultra-processed foods, regardless of the overall dietary philosophy.
The quantity of food may matter almost as much as the quality. For nearly 100 years, calorie restriction has remained the most reproducible nutritional intervention for extending lifespan in laboratory animals. Whether intentional calorie restriction should be recommended for healthy humans remains uncertain, but one message is difficult to ignore: chronic overnutrition appears to accelerate many of the biological processes associated with aging.
This means that maintaining a healthy body weight and good metabolic health is likely more important than including or avoiding any specific food. And indeed, there is still no convincing evidence that blueberries, turmeric, green tea, resveratrol, NMN, or any neutraceutical dramatically slows human aging on its own.
It’s not sexy, but the keyword is consistency: instead of a trendy fountain-of-youth shortcut, the literature overwhelmingly suggests that healthy aging emerges from sustained dietary patterns practiced over years and decades. The people who appear to age most successfully tend to eat mostly whole foods, emphasize plants, limit ultra-processed foods, avoid chronic overconsumption, and maintain good metabolic health.
As longevity research continues to evolve, scientists will undoubtedly refine these recommendations and may reveal surprising breakthroughs. But so far, across thousands of studies examining nutrition and aging, the overall message has remained remarkably steady: the fundamentals matter far more than the fads.
And, if that might seem like a disappointing conclusion, the headline remains that "Yes, how and what we eat absolutely can slow the aging process". This doesn’t just allow us to live longer, but also more gracefully. While we can't control the passage of time, we may have more influence over how well we age than previously believed.
Can nutrition really slow aging? Growing evidence suggests that nutrition influences many biological processes associated with aging, although no diet has yet been proven to dramatically extend human lifespan.
Can you reverse your biological age? Some lifestyle interventions have improved biomarkers of biological aging, but whether this truly "reverses" aging remains an active area of research.
What is the best anti-aging diet? No single diet has been proven superior. The strongest evidence supports dietary patterns centred on whole, minimally processed foods and abundant plant foods.
Do anti-aging supplements work? Despite the hype, no supplement has been convincingly shown to slow human aging. The evidence for healthy dietary patterns is far stronger.
Which foods appear to accelerate biological aging? Diets high in ultra-processed foods are consistently associated with less favourable biomarkers of biological aging and poorer long-term health outcomes.
Alonso-Pedrero, L., Ojeda-Rodríguez, A., Martínez-González, M. A., Zalba, G., Bes-Rastrollo, M., & Marti, A. (2020). Ultra-processed food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (sun) project. The American Journal of Clinical Nutrition, 111(6), 1259–1266. https://doi.org/10.1093/ajcn/nqaa075
An anti-wrinkle diet: Nutritional strategies to combat oxidation, inflammation and glycation - pubmed. (n.d.). https://pubmed.ncbi.nlm.nih.gov/32196147/
Can ageing be slowed down? . Max Planck Institute for Biology of Ageing. (n.d.-a). https://www.age.mpg.de/can-ageing-be-slowed-down
Can we slow aging? . National Institutes of Health (NIH). (n.d.). https://www.nih.gov/news-events/nih-research-matters/can-we-slow-aging
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020). Diet and skin aging—from the perspective of Food Nutrition. Nutrients, 12(3), 870. https://doi.org/10.3390/nu12030870
Castelli, S., Aiello, G., Aiello, V., Massimino, E., Pieri, M., Amoah, I., Lombardo, M., Tripodi, G., & Baldelli, S. (2026). Nutritional Strategies and aging: Current evidence and future directions. Molecules, 31(5), 756. https://doi.org/10.3390/molecules31050756
Das, G., Kameswaran, S., Ramesh, B., Bangeppagari, M., Nath, R., Das Talukdar, A., Shin, H.-S., & Patra, J. K. (2024). Anti-aging effect of traditional plant-based food: An overview. Foods, 13(23), 3785. https://doi.org/10.3390/foods13233785
Dominguez, L. J., Veronese, N., & Barbagallo, M. (2023). Dietary patterns and healthy or unhealthy aging. Gerontology, 70(1), 15–36. https://doi.org/10.1159/000534679
Duan, H., Pan, J., Guo, M., Li, J., Yu, L., & Fan, L. (2022). Dietary strategies with anti-aging potential: Dietary patterns and supplements. Food Research International, 158, 111501. https://doi.org/10.1016/j.foodres.2022.111501
Fekete, M., Szarvas, Z., Fazekas-Pongor, V., Feher, A., Csipo, T., Forrai, J., Dosa, N., Peterfi, A., Lehoczki, A., Tarantini, S., & Varga, J. T. (2022). Nutrition Strategies Promoting Healthy Aging: From improvement of cardiovascular and Brain Health to prevention of age-associated diseases. Nutrients, 15(1), 47. https://doi.org/10.3390/nu15010047
Fitzgerald, K. N., Hodges, R., Hanes, D., Stack, E., Cheishvili, D., Szyf, M., Henkel, J., Twedt, M. W., Giannopoulou, D., Herdell, J., Logan, S., & Bradley, R. (2021). Potential reversal of epigenetic age using a diet and lifestyle intervention: A pilot randomized clinical trial. Aging, 13(7), 9419–9432. https://doi.org/10.18632/aging.202913
Fitzgerald, K., & Hanley, K. (2023). Younger you: Reduce your bio age-and live longer, better. Hachette Go.
Fransquet, P. D., Wrigglesworth, J., Woods, R. L., Ernst, M. E., & Ryan, J. (2019). The epigenetic clock as a predictor of disease and mortality risk: A systematic review and meta-analysis. Clinical Epigenetics, 11(1). https://doi.org/10.1186/s13148-019-0656-7
Gao, L., Liu, X., Luo, X., Lou, X., Li, P., Li, X., & Liu, X. (2023). Antiaging effects of dietary supplements and natural products. Frontiers in Pharmacology, 14. https://doi.org/10.3389/fphar.2023.1192714
Gruber, H.-J., Semeraro, M. D., Renner, W., & Herrmann, M. (2021). Telomeres and age-related diseases. Biomedicines, 9(10), 1335. https://doi.org/10.3390/biomedicines9101335
Hu, F. B. (2023). Diet strategies for promoting healthy aging and longevity: An epidemiological perspective. Journal of Internal Medicine, 295(4), 508–531. https://doi.org/10.1111/joim.13728
Inflammaging: From mechanisms to clinical implications and targeted interventions. (2026). Aging and Disease. https://doi.org/10.14336/ad.2025.1557
Kaufman, M. W., DeParis, S., Oppezzo, M., Mah, C., Roche, M., Frehlich, L., & Fredericson, M. (2024). Nutritional supplements for healthy aging: A critical analysis review. American Journal of Lifestyle Medicine, 19(3), 346–360. https://doi.org/10.1177/15598276241244725
Knott, A. (n.d.). Biological aging may be slowed by eating this nutrient. EatingWell. https://www.eatingwell.com/this-nutrient-slows-biological-aging-11893397
Lee, M. B., Hill, C. M., Bitto, A., & Kaeberlein, M. (2021). Antiaging diets: Separating fact from fiction. Science, 374(6570). https://doi.org/10.1126/science.abe7365
Li, C., Zhang, Y., Zhang, K., Fu, H., Lin, L., Cai, G., Zhang, X., Yang, X., Zhang, Z., Yang, Z., & Zhang, B. (2024). Association between ultra-processed food consumption and leucocyte telomere length: A cross-sectional study of UK biobank. The Journal of Nutrition, 154(10), 3060–3069. https://doi.org/10.1016/j.tjnut.2024.05.001
Martínez Leo, E. E., Peñafiel, A. M., Hernández Escalante, V. M., & Cabrera Araujo, Z. M. (2021). Ultra-processed diet, systemic oxidative stress, and breach of immunologic tolerance. Nutrition, 91–92, 111419. https://doi.org/10.1016/j.nut.2021.111419
Ng, J. Y., Yan Ng, X. M., Wong, Q. Y., & Chew, F. T. (2025). Dietary interventions in skin ageing: A systematic review and meta-analysis. Journal of Physiological Anthropology, 44(1). https://doi.org/10.1186/s40101-025-00408-4
Ornish, D., Lin, J., Chan, J. M., Epel, E., Kemp, C., Weidner, G., Marlin, R., Frenda, S. J., Magbanua, M. J., Daubenmier, J., Estay, I., Hills, N. K., Chainani-Wu, N., Carroll, P. R., & Blackburn, E. H. (2013). Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. The Lancet Oncology, 14(11), 1112–1120. https://doi.org/10.1016/s1470-2045(13)70366-8
Ornish, D., Lin, J., Daubenmier, J., Weidner, G., Epel, E., Kemp, C., Magbanua, M. J., Marlin, R., Yglecias, L., Carroll, P. R., & Blackburn, E. H. (2008). Increased telomerase activity and comprehensive lifestyle changes: A pilot study. The Lancet Oncology, 9(11), 1048–1057. https://doi.org/10.1016/s1470-2045(08)70234-1
Panoff, L. (n.d.). Is there a diet to reverse biological age? what science shows (and how to do it) . good health by hims. https://www.hims.com/guides/diet-to-reverse-biological-age
Polom, J., & Boccardi, V. (2025). Employing nutrition to delay aging: A plant-based telomere-friendly dietary revolution. Nutrients, 17(12), 2004. https://doi.org/10.3390/nu17122004
Smith, L., Luchini, C., Demurtas, J., Soysal, P., Stubbs, B., Hamer, M., Nottegar, A., Lawlor, R. T., Lopez-Sanchez, G. F., Firth, J., Koyanagi, A., Roberts, J., Willeit, P., Waldhoer, T., Loosemore, M., Abbs, A. D., Johnstone, J., Yang, L., & Veronese, N. (2019). Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies. Ageing Research Reviews, 51, 1–10. https://doi.org/10.1016/j.arr.2019.02.003
Steele, A. (n.d.). The anti-ageing diet: 6 science-backed changes to protect your skin, body and brain from getting older | BBC Science Focus Magazine. BBC Science Focus. https://www.sciencefocus.com/the-human-body/anti-ageing-diet
Vinci, G., Davì, F., Pellegrino, T., Fusco, R., Cordaro, M., & Di Paola, R. (2025). Main dietary patterns for healthy aging and well-being. Nutrients, 17(12), 2009. https://doi.org/10.3390/nu17122009
What is biological age and how can you measure it?. Max Planck Institute for Biology of Ageing. (n.d.-b). https://www.age.mpg.de/what-is-biological-age
Zhu, H., Ou, X., Qian, H., & Dundrup, N. (2024). Focus on the nutritional intervention for Healthy Aging and human wellness based on the “environment-food-human” web. Frontiers in Nutrition, 11. https://doi.org/10.3389/fnut.2024.1398916
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